Cognitive Training for Emotion Regulation in Psychotic Disorders
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-60
SponsorUniversity of Georgia
About this trial
The current study examines the efficacy of a cognitive training intervention for improving emotion regulation in psychotic disorders. it is hypothesized that the cognitive training program will enhance prefrontal activation, leading to enhanced emotion regulation.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
diagnostic and statistical manual fifth edition diagnosis of schizophrenia or schizoaffective disorder
18-60 years old
speaks English
premorbid intelligence quotient > 70
Disqualifiers
history of intellectual disability or neurological disorder
history of traumatic brain injury with loss of consciousness > 10 minutes or behavioral sequelae
substance use disorder within the last 6 months (other than nicotine)
4) endorsement of MRI exclusion factors
Trial design
Design model
Parallel
Treatments tested in this trial
Emotional working memory training
BehavioralParticipants will complete an emotional working memory n-back training program that progressively increases difficulty and has been shown to enhance prefrontal activity in a non-psychiatric sample
Placebo working memory training
BehavioralWorking memory training that does not involve emotional stimuli using an N-back training program
Treatment groups
70 Participants
are divided into 2 treatment groupsGroup A: Cognitive trainingExperimental treatment 1 intervention
Group B: Placebo trainingPlacebo comparator 1 intervention
Trial outcomes
Primary outcomes
1
Prefrontal blood oxygen level dependent activation in the prefrontal cortex
blood oxygen level dependent change in the prefrontal cortex as measured using functional magnetic resonance imaging. This will be calculated as a change from baseline to follow-up on the contrast score (unpleasant passive viewing condition - reappraisal) on the emotion regulation reappraisal task
Time frame
Change from baseline to 15 days or 30 daysSponsors and contacts
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Source ClinicalTrials.gov