Cohort of Twin Pregnancy and the Offspring
ConditionTwin Pregnancy
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18+
SponsorFudan University
About this trial
Twin pregnancy increases the risk of maternal and fetal complications, which include gestational hypertension, premature labor, twin-to-twin transfusion syndrome, intrauterine growth restriction, anemia, amniotic fluid abnormalities. Comprehensively understanding the molecular mechanisms of the disease and identification of markers contribute to development of novel therapeutic approaches. In addition, the twin pregnancy, especially the monochorionic, is an essential model of "experiments of nature". This model can be applied to distinguish the epigenetic differences of twins in utero and after birth in the same genomic context. The aim of the study is to constitute a prospective cohort of twin pregnancies and the offspring.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Maternal age >18 years old.
Twin pregnancy.
Disqualifiers
Fetal chromosomal or congenital abnormalities.
Stillbirth.
Trial population
Woman with twin pregnancy and their offspring within 3 years old.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
All pregnant women with a twin pregnancy and the offspring
Other interventionNo intervention
Treatment groups
1,000 Participants
are divided into 1 treatment groupGroup A: twins1 intervention
Trial outcomes
Primary outcomes
1
The incidence of maternal and fetal complications
The incidence of preeclampsia, gestational diabetes mellitus, premature delivery, postpartum hemorrhage, twin to twin transfusion syndrome, selective intrauterine growth restriction.
Time frame
From confirmation of pregnancy to 42 days postpartum2
RNA profiles in placentas of twin pregnancy measured by RNA-sequencing
Levels of placental RNA expression.
Time frame
Immediately after delivery3
Global DNA methylation in placentas of twin pregnancy measured by whole-genome bisulfite sequencing
Global DNA methylation levels in placentas of twin pregnancy.
Time frame
Immediately after delivery4
Protein profiles in placentas of twin pregnancy measured by tandem mass tags quantification.
Levels of proteins in placentas of twin pregnancy.
Time frame
Immediately after deliverySecondary outcomes
1
The level of twin Neurodevelopment assessed by Gesell Developmental Schedules
The parameters in Gesell Developmental Schedules including adaptive, gross motor, fine motor, language, and social function.
Time frame
Age at 3 years of the offspring2
The incidence of long term maternal complications
Including hypertension, diabetes mellitus and metabolic disease.
Time frame
Three years after deliverySponsors and contacts
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Source ClinicalTrials.gov