Cohort Primary Hyperparathyroidism
ConditionPrimary Hyperparathyroidism
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorNantes University Hospital
About this trial
CoHPT is a prospective, monocentric, observational cohort including all patients diagnosed with primary hyperparathyroidism in Nantes University Hospital, aiming to study the outcomes associated with parathyroidectomy. Clinical and biochemical evaluation is performed at the inclusion, and 6, 12, 36 and 60 months. A biocollection is collected. The main hypotheses are that parathyroidectomy could improve cardiovascular, renal, bone, and cardiovascular outcomes along with quality of life.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
Age < 18
Pregnancy / lactation
Adults underguardianship
Secondary/tertiary hyperparathyroidism
Trial population
All consecutive patients consulting for sporadic primary hyperparathyroidism in Nantes University Hospital
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Occurrence of cardiovascular events, after parathyroidectomy for primary hyperparathyroidism
Cardiovascular events include myocardial infarction, cerebrovascular and peripheral arterial events
Time frame
Between inclusion and 12 months after surgery2
Change in LDL-cholesterol concentration after surgery
Plasma LDL-cholesterol (mg/dL) will be directly measured using enzymatic method
Time frame
Between inclusion and 12 months after surgery3
Change in HDL-cholesterol concentration after surgery
Plasma HDL-cholesterol (mg/dL) will be measured using enzymatic method
Time frame
Between inclusion and 12 months after surgery4
Change in plasma triglycerides concentration after surgery
Plasma triglycerides (mg/dL) will be measured using enzymatic method
Time frame
Between inclusion and 12 months after surgerySecondary outcomes
1
Occurrence of cardiovascular events, after parathyroidectomy for primary hyperparathyroidism
Cardiovascular events include myocardial infarction, cerebrovascular and peripheral arterial events
Time frame
Between inclusion and 60 months after surgery2
Change in LDL-cholesterol concentration after surgery
Plasma LDL-cholesterol (mg/dL) will be directly measured using enzymatic method
Time frame
Between inclusion and 60 months after surgery3
Change in HDL-cholesterol concentration after surgery
Plasma HDL-cholesterol (mg/dL) will be measured using enzymatic method
Time frame
Between inclusion and 60 months after surgery4
Change in plasma triglycerides concentration after surgery
Plasma triglycerides (mg/dL) will be measured using enzymatic method
Time frame
Between inclusion and 60 months after surgerySponsors and contacts
Click on the lead sponsor to view all of their trials.
Nantes University Hospital
Lead sponsor
Institut National de la Santé Et de la Recherche Médicale, France
Collaborator
Source ClinicalTrials.gov