Cohort Study on Treatment Comes of Catheter-based Therapy in Patients With Acute Pulmonary Embolism in Hong Kong

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorChinese University of Hong Kong

About this trial

This retrospective cohort study (Hong Kong PECT Registry) compares treatment outcomes between different percutaneous catheter-based therapies in patients with acute pulmonary embolism (PE). PE is a critical condition with potential for rapid deterioration and mortality before treatment. While availability of catheter-based therapy contributed to the declining mortality rates of PE, selecting the appropriate intervention remains key. There are primarily two modes of therapies available: Catheter-directed thrombolysis and Aspiration thrombectomy (e.g., Penumbra, Flowtriever, AlphaVac) Given limited direct comparisons between these methods, the study will evaluate their efficacy, safety, and clinical outcomes of these treatment strategies in acute PE patients.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients who is admitted with a diagnosis of acute pulmonary embolism

Patient who receives any types of catheter-based therapy for acute pulmonary embolism.

Disqualifiers

nil. This is a all-comer registry.

Trial population

This registry aims to evaluate the efficacy and safety of patients with acute PE treated with catheter-based therapy.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • catheter-based therapy

    Device

    catheter-based therapy

Treatment groups

1,000 Participants
are divided into 2 treatment groups
Group A: catheter-directed thrombolysis (CDT)1 intervention
Group B: Aspiration thrombectomy (AT)1 intervention

Trial outcomes

Primary outcomes

1

Inpatient mortality rates

death of a patient occurring during the index hospitalization of pulmonary embolism.

Time frame
baseline, through hospital stay, an average of 7 days

Secondary outcomes

1

procedural related complications

safety outcomes

Time frame
baseline, 72 hours post operation
2

major bleeding (as defined by BARC)

safety outcomes

Time frame
baseline, 72 hours post operation
3

hemoglobin change within 72 hours of the procedure

safety outcomes

Time frame
baseline, 72 hours post operation
4

change in the right ventricle to left ventricle ratio

procedural efficacy

Time frame
baseline, 72 hours post operation

Other outcomes

1

90 days overall mortality rate

90 days mortality rate

Time frame
baseline, 90 days
2

PE recurrence by 90 days

recurrence of PE by 90 days

Time frame
baseline, 90 days

Sponsors and contacts

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Chinese University of Hong Kong

Lead sponsor

China Medical University, Taiwan

Collaborator