RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that may occur in RNA and identify biomarkers related to cancer.
PURPOSE: This research study is collecting and analyzing lung tissue samples from patients undergoing surgery for non-small cell lung cancer.
Diagnosis of non-small cell lung cancer
Clinical stage I and II disease
Resectable disease and complete surgical resection planned
Treated on companion studies at Vanderbilt University, the Veterans Administration hospital, St. Thomas, and Vanderbilt-Ingram Cancer Center Affiliate Network
Chemotherapy before surgery
Radiotherapy before surgery
People who have clinical stage I and II non-small cell lung cancer
Cohort
Prospective
gene expression analysis
GeneticBlood and lung tissue collection
microarray analysis
GeneticBlood and lung tissue collection
protein expression analysis
GeneticBlood and lung tissue collection
biologic sample preservation procedure
Other interventionBlood and lung tissue collection
laboratory biomarker analysis
Other interventionBlood and lung tissue collection
matrix-assisted laser desorption/ionization time of flight mass spectrometry
Other interventionBlood and lung tissue collection
Protein and RNA expression fingerprints from collected samples
Development of statistical and computational methods to model relationship of data and clinical outcomes
Correlation of protein and RNA expression fingerprints with recurrence (local and/or distant) and survival
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Vanderbilt-Ingram Cancer Center
Lead sponsor
National Cancer Institute (NCI)
Collaborator
