This research trial collects and stores blood, tissue, and bone marrow specimens from patients with cancer or blood disorders, and healthy volunteers to study the immune system in a variety of different types of experiments, as well as associated clinical data as appropriate, focused on understanding mechanisms of immunotherapy.
All patients known to have cancer, an immune-mediated hematologic diagnosis, or a healthy normal volunteer
Definition of immune-mediated hematologic diagnosis: diagnoses for which immune dysfunction and/or immune system directed therapy (eg. aplastic anemia, autoimmune hemolytic anemia, immune thrombocytopenic purpura [ITP], etc.) are involved
Definition of healthy normal volunteer: persons lacking diagnoses of any type of cancer, diabetes, cardiovascular diseases, non-hematologic autoimmune disease (eg. systemic lupus erythematosus [SLE], rheumatoid arthritis [RA], Crohn's disease) and not taking any immunosuppressive medications
Patients must have been seen in the Norris Hospital and outpatient clinics, or the Los Angeles County (LAC)-University of Southern California (USC) Medical Center or outpatient clinics; healthy volunteers can be recruited without any physician visit appointments since their labs are strictly for clinical research and not for personal health issues unrelated to the project
Unable to give informed consent to specimen collection
Known human immunodeficiency virus (HIV) positive status
Persons taking any type of immunosuppressive medication are excluded from participating as healthy normal volunteers
Any patient for whom specimen collection is judged to be unsafe (for example, for patients unable to establish venous access)
Patients known to have cancer, an immune-mediated hematologic diagnosis, or a healthy normal volunteer
Case-control
Retrospective
Biospecimen Collection
Procedure/SurgeryUndergo collection of peripheral blood, bone marrow, and tissue
Laboratory Biomarker Analysis
Other interventionCorrelative studies
Questionnaire Administration
Other interventionAncillary studies
Sample collection for immunology studies from patients with cancer or blood disorders, and healthy volunteers
Tissue, blood, and bone marrow samples collected will be used to identify changes in immune system parameters in patients receiving immunotherapies (including immune checkpoint inhibitors, immunostimulatory/immunomodulatory agents, cellular therapies, stem cell transplantation) and compare to changes in patients receiving conventional chemotherapy, targeted-agent therapy, and healthy normal volunteers using multiparameter flow cytometry, time-of-flight mass cytometry, cytokine quantification, functional analysis of immune cell subsets isolated via fluorescence activated cell sorting (FACS), and genetic and proteomic techniques (deoxyribonucleic acid \[DNA\] sequencing, ribonucleic acid \[RNA\]-sequence \[Seq\], reverse transcriptase-polymerase chain reaction \[RT-PCR\], Western blot).
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University of Southern California
Lead sponsor
National Cancer Institute (NCI)
Collaborator
