Collection of Primary Human

ConditionNasal Disease

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-90

SponsorUniversity Hospital, Tours

About this trial

Treatment and prevention of respiratory infections are of great interest in many medical areas. Create a physical device covered by primary human nasal cells could be very usefull in order to analyse delivery and efficiency of drugs. In this context the aim of this project is to create a collection of primary cells from the human nasal epithelium.

This collection will be realised during programmed surgery, thanks to a specific device dedicated to collect nasal cells. Then the cells will be sent to the lab in order to grow at the air-liquid interface, which is an excellent 'ex vivo' model for their study.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Adult patients (age > 18 years) whose native language is French, or who understands French.

Affiliation with a French social security system (CMU accepted).

Informed consent, written and signed by the participant.

Planned rhinological surgery (meatotomy, septoplasty or turbinoplasty for example, but other surgeries as well)

Disqualifiers

Patients under court protection, guardianship or curatorship.

Pregnant or breast-feeding women (positive pregnancy test for women of childbearing age).

Patients presenting a major alteration of the mucosa or a malignant rhinosinus pathology.

Trial design

Design model

Single group

Treatments tested in this trial

Collection of nasal cells during programme surgery
Other intervention
During programmed surgery (meatotomy, septoplasty or turbinoplasty for example, or other programmed surgeries), the surgeon will take an atraumatic sample from the nasal cavity using a dedicated device (brush) from the healthy nasal mucosa.

Treatment groups

100 Participants

are divided into 1 treatment group

Group A: Patient with programmed surgeryOther 1 intervention

Trial outcomes

Primary outcomes

Percentage of viability of nasal epithelial cells from the operating room to laboratory

Collect nasal epithelial cells that can be grown in vitro in an air-liquid interface

Time frame

6 hours

Secondary outcomes

Percentage of efficacy of the procedure

Percentage of samples that can actually be cultivated following transfer to the laboratory.

Time frame

3 years

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University Hospital, Tours

Lead sponsor

Source ClinicalTrials.gov

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