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Combined Anodal Transcranial Direct Current Stimulation (tDCS) and Cognitive Training and Decision-making

ConditionsImpulsivityDecision Making
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-40
SponsorDr. Najat Khalifa

About this trial

This study aims to (i) assess the effects of combined tDCS and cognitive training on decision-making on a trained task (Iowa Gambling Task; IGT); and (ii) test generalization to a closely related cognitive domain, namely motor impulsivity. It is hypothesized that combined anodal tDCS and cognitive training will result in more advantageous decisions and better impulse control than combined sham tDCS and cognitive training.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Consenting volunteers aged between 18 and 40.

Disqualifiers

Individuals with epilepsy, other neurological conditions and history of significant head injury will be excluded.

Individuals with a history of substance misuse, major mental disorder and those receiving psychotropic medication will be also excluded.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Anodal transcranial Direct Current Stimulation (tDCS)

    Other intervention

    Non-invasive brain stimulation

  • Cognitive training

    Behavioral

    Iowa Gambling Task will be used for cognitive training

  • Sham transcranial Direct Current Stimulation (tDCS)

    Other intervention

    Non-invasive brain stimulation

Treatment groups

60 Participants
are divided into 2 treatment groups
Group A: Combined anodal tDCS and cognitive trainingExperimental treatment 2 interventions
Group B: Combined sham tDCS and cognitive trainingSham comparator 2 interventions

Trial outcomes

Primary outcomes

1

Iowa Gambling Task (IGT) net scores

IGT is a measure of decision making under conditions of uncertainty and risk.

Time frame
Change from baseline after 20 minutes of combined cognitive training and tDCS stimulation

Secondary outcomes

1

Stop Signal Task (SST) reaction time

SST is a measure of inhibitory control

Time frame
Change from baseline after 20 minutes of combined cognitive training and tDCS stimulation
2

Urgency, Perseveration, Premeditation, Sensation Seeking + Positive Urgency (UPPS+P) Impulsive Behavior Scale total scores

UPPS+P is a 59 item self-report measure of trait impulsivity. Each item is rated on a scale of 1-4 (1= totally disagree, 4=totally agree) yielding a total score out of 216 (range=59 - 216) Higher scores denote higher impulsivity.

Time frame
Baseline
3

Abbreviated Profile of Mood States (POMS) Total Mood Disturbance score

Abbreviated POMS is a 40-item measure of current mood states. Each item is rated on a scale of 0-4 (0=Not at all, 4=Extremely). The total Mood Disturbance score is calculated by summing the totals for the negative subscales (tension, depression, anger, fatigue, confusion) and then subtracting the totals for the positive subscales (vigour, esteem related affect) and then adding a constant 100. Higher scores denote greater mood disturbance.

Time frame
Baseline

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Dr. Najat Khalifa

Lead sponsor

Queen's University

Sponsor institution

University of Nottingham

Collaborator

Source ClinicalTrials.gov
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