The purpose of this study is to improve treatment outcomes for patients with chronic anal fissure.
• Patients with chronic anal fissure with spasm of anal sphincter
• Inflammatory diseases of the colon
Pectenosis
Previous surgical interventions on the anal canal
IV grade internal and external hemorrhoids
Parallel
excision of the anal fissure with further relaxation of the internal sphincter with botulinum toxin A
Procedure/Surgerypatients undergo excision of the fissure in combination with drug relaxation of the internal sphincter with botulinum toxin type A at a dosage of 40 units of action; an additional injection of platelet-rich plasma is added
Anal sphincter insufficiency
Frequency of anal sphincter insufficiency according to the Wexner scale
2-item pain intensity (P2)
Self reported pain intensity after the defecation and during the day after the surgical intervention. Each item is scored 0-10 (0 = no pain; 10 = pain as bad, as can can be).
Non-Healing Wound
Frequency of post-operative wound epithelialization
Profilometry /sphincterometry findings
Internal sphincter spasm or local internal sphincter spasm by the data of anorectal profilometry / or anorectal sphincterometry
Temporary disability
Duration of temporary disability
Click on the lead sponsor to view all of their trials.
