Health TrialsbyHealthPanel

Combined Motor Imagery and Vestibular Rehab for MS

ConditionMultiple Sclerosis (MS) - Relapsing-remitting
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorMedipol University

About this trial

This trial investigates the first combined use of motor imagery and vestibular rehabilitation in multiple sclerosis, aiming to evaluate their joint effect on balance, cognition, and quality of life.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Diagnosis of Multiple Sclerosis (MS) Confirmed using McDonald Criteria

Patient diagnosed relapsing-remitting multiple sclerosis (RRMS).

Mild MS between 0-3 according to PDDS.

Age from (18-45)

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

  • Motor Imagery + Vestibular Rehabilitation group

    Behavioral

    This 8-week program, 3 sessions/week, 55- 60 min each, includes 4 steps: Warm-up (5 min): Breathing exercises progressing from basic diaphragmatic and pursed-lip breathing (weeks 1-2), light movement with breathing (weeks 3-4), to Inspiratory Muscle Training device (weeks 5-8). Motor Imagery (15 min): Foundational phase (weeks 1-2) imagining basic movements, skills building (weeks 3-4) with functional daily tasks, advanced phase (weeks 5-8) imagining complex tasks, environmental and cognitive challenges (e.g., sports, obstacle navigation, walking on uneven surfaces). Vestibular Rehabilitation (15 min): Foundational (weeks 1-2) gaze stabilization and static balance (VOR, VSR, VCR), dynamic balance and dual-task exercises (weeks 3-6), advanced functional balance and vestibular-cognition integration (weeks 7-8). Cool-down (10 min): Relaxation and symptom monitoring to prevent overexertion, dizziness, or fatigue.

  • Conventional therapy group

    Behavioral

    This 8-week program, 3 sessions/week, 55- 60 min each, includes: Warm-up: Seated/standing marching, neck and shoulder stretching. Strength \& Functional Movements: Sit-to-stand, side leg raises, step-ups. Core \& Upper Body: Bridge exercise, seated core activation, seated leg lifts, wall push-ups, seated shoulder press. Flexibility \& Balance: Calf and hamstring stretches, spinal flexibility, single-leg stance, lunges, tandem walking. Cool-down: Deep breathing and gentle stretching.

Treatment groups

30 Participants
are divided into 2 treatment groups
Group A: Motor Imagery + Vestibular Rehabilitation GroupExperimental treatment 1 intervention
Group B: Conventional GroupOther 1 intervention

Trial outcomes

Primary outcomes

1

Change in Cognitive Function (Montreal Cognitive Assessment [MoCA] Score)

It is a cognitive screening tool commonly used in clinics and research to assess individual cognitive impairment and its severity. It helps therapists evaluate a patient's cognitive function and identify changes over time by assessing mental capacity functions and takes about 10-15 minutes to complete., which includes Attention \& Concentration, Executive Functions, Memory, Language, Visuospatial Skills and Orientation (19). 1. The test is scored out of 30 points. 2. A score of 26 or higher is considered normal. 3. Scores below 26 may indicate mild cognitive impairment or early dementia.

Time frame
Baseline and 8 weeks after intervention
2

Change in Balance Berg Balance Scale \[ABBS] Score)

To assess balance and fall risk in Arabic-speaking patients with neurological disorders, lower scores indicate more severe balance problems (23). 1. 41-56: Low fall risk 2. 21-40: Moderate fall risk. 3. 0-20: High fall risk."

Time frame
Baseline (Week 0) and Post-intervention (Week 8)
3

Change in Vestibular Function (Dynamic Visual Acuity [DVA] Test)

DVA assesses visual acuity during head movement to evaluate vestibulo-ocular reflex integrity.It is a functional test designed to evaluate the integrity of the vestibulo-ocular reflex (VOR), which stabilizes the eyes during head motion. DVA is commonly employed to detect vestibular dysfunction and is particularly useful for evaluating vestibular function in patients experiencing dizziness, balance disorders, or conditions such as multiple sclerosis (MS), where vestibular dysfunction is common

Time frame
Baseline and Week 8.
4

Change in Vestibular Function (Head Impulse Test [HIT])

Bedside assessment of semicircular canal/VOR function. Outcome recorded as presence/absence of corrective saccades and qualitative clinician rating of gain; improvement indicates better vestibular function.It is a clinical test used to identify deficits in the semicircular canals, especially the horizontal canal, and is useful for detecting peripheral vestibular deficits. It assesses the ability of the vestibulo-ocular reflex (VOR) to maintain stable vision during rapid, unpredictable head movements

Time frame
Baseline and Week 8

Secondary outcomes

1

Change in Quality of Life (Multiple Sclerosis Impact Scale-29 \[MSIS-29]

The Multiple Sclerosis Impact Scale-29 (MSIS-29) is a clinical tool used by patients to assess the impact of MS on their quality of life. The questionnaire consists of 29 questions and evaluates both physical and psychological well-being, helping to determine how MS affects daily life

Time frame
Baseline and Week 8.

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Medipol University

Lead sponsor

Source ClinicalTrials.gov
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