Combined Recanalization Therapy for Acute Large Vessel Occlusion Stroke
ConditionStroke
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorTianjin Huanhu Hospital
About this trial
The purpose of this clinical trial is to evaluate the efficacy and safety of combined recanalization therapy in patients who cannot be recanalized by acute large vessel occlusive stroke. The main questions it aims to answer are:
1、Proportion of subjects with mRs score of 0-1 at 90 days after surgery
Participants will:
1、In acute large vessel occlusive stroke, if traditional means cannot be recanalized, combined recanalization surgery (including arteriotomy and thrombectomy, cerebrovascular bypass surgery) is performed.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age: 18-75.
According to the current guidelines, there is a MT indication.
Before stroke, mRS ≤2;
ASPECTS ≥6;
Disqualifiers
Comorbid hemorrhagic vascular disease such as intracranial aneurysm or vascular malformation or other planned cerebrovascular surgery that may alter cerebral hemodynamics or lead to stroke;
unstable angina or myocardial infarction, congestive heart failure within the previous 6 months;
Pregnancy or perinatal period;
Hematologic disorders resulting in coagulation disorders;
Trial design
Design model
Parallel
Treatments tested in this trial
Surgery
Procedure/SurgeryRecombined recanalization surgery
Treatment groups
64 Participants
are divided into 2 treatment groupsGroup A: experiment group（surgical treatment）Experimental treatment 1 intervention
Group B: control group（conservative therapy）No intervention 0 interventions
Trial outcomes
Primary outcomes
1
Proportion of subjects with mRs score of 0-1 at 90 days after surgery
Time frame
90 days after recombined recanalization surgerySecondary outcomes
1
Changes in NIHSS score at 24 hours after surgery, 7 days after surgery, 30 days after surgery and 90 days after surgery compared with baseline;
Time frame
90 days after recombined recanalization surgery2
The mRs score changed from baseline at 90 days after surgery
Time frame
90 days after recombined recanalization surgery3
Change from baseline in MOCA score at 90 days after surgery
Time frame
90 days after recombined recanalization surgery4
Change from baseline in MMSE score at 90 days after surgery
Time frame
90 days after recombined recanalization surgerySponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov