Comparative Analysis of Cost-effectiveness Between Sulfonylureas and DPP4 Inhibitors in Combination With Metformin in Treatment of Type 2 Diabetic Patients : A Retrospective, Observational Study.

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorBangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

About this trial

The aim of this study is to compare the cost effectiveness of Sulfonylureas and DPP4-inhibitors in combination with Metformin among type2 diabetic patients diagnosed for 2-5 years. Glycemic status and other clinical outcome are compared in between two groups and ICER are compared.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

New onset type2 diabetes mellitus diagnosed for 2 -5 years.

Taking either sulfonylurea or DPP4 inhibitors combined with Metformin from the time of diagnosis.

Age 18 years or above.

Both male and female.

Disqualifiers

Unwillingness to participate or unwillingness to give written informed consent.

Patients on Insulin therapy or monotherapy with metformin since the time of diagnosis.

Taking other than sulfonylurea or DPP4 inhibitors combined with Metformin from the time of diagnosis.

Diabetes related complications at the time of diagnosis.

Trial population

patients attending out patient department of BIRDEM General hospital,Shahbag, Dhaka, which is a tertiary care hospital and patients attending Siddhirganj Diabetic center, a secondary care level diabetes center

Trial design

Design model

Other

Time perspective

Retrospective

Treatments tested in this trial

  • sulfonylurease with metformin, DPP4 inhibitors with Metformin

    Drug

    Oral hypoglycemic agents

Treatment groups

200 Participants
are divided into 2 treatment groups
Group A: Group A- type 2 diabetic patients having sulfonylurease with metformin1 intervention
Group B: Group B- type 2 diabetic patients having DPP4 inhibitors with metformin1 intervention

Trial outcomes

Primary outcomes

1

HbA1c%

achievment of target HbA1 less than 7%

Time frame
2-5years

Secondary outcomes

1

Insulin therapy

requirement of insulin therapy

Time frame
2-5years
2

hospitalization

requirement of hospitalization

Time frame
2-5years
3

3rd line therapy

addition of any 3rd drug

Time frame
2-5years
4

nephropathy

development of nephropathy

Time frame
2-5years

Other outcomes

Sponsors and contacts

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