In our thesis, we will compare the effectiveness of low-intensity shock wave versus acetylcholine iontophoresis as a possible new therapy for microcirculation changes in type 2 diabetic neuropathy
Patients have to be symptomatically stable with type 2 diabetes mellitus complicated with peripheral neuropathy.
Optimized pharmacological treatment that will be remained unchanged throughout the study.
Implanted cardiac pacemakers.
Patients with known skin allergies.
Presence of skin inflammations.
Peripheral vascular disease.
Parallel
Low-intensity extracorporeal shock wave
DeviceAcetylcholine iontophoresis• The Iontophoresis comprises of electric impulses from a low voltage galvanic current stimulation unit to drive ions (Ach) (1%) into soft tissue structures.
Electrophysiological investigations of peripheral nerves (latency, amplitude and velocity of peripheral nerves)
Electrophysiological investigations of peripheral nerves were measured pre and post treatment for both groups (latency, amplitude and velocity of peripheral nerves)
Nitric oxide laboratories for measurement of nitric oxide level
Nitric oxide laboratories for measurement of nitric oxide level were measured pre and post treatment for both groups.
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