Health TrialsbyHealthPanel

Comparative Efficacy of Amoxicillin, Metronidazole, and Chlorhexidine in Preventing Alveolar Osteitis

ConditionAlveolar Osteitis
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-40
SponsorKhyber Medical University Peshawar

About this trial

This study will compare the effectiveness of amoxicillin, metronidazole, and chlorhexidine in preventing alveolar osteitis (dry socket) following lower third molar extraction. Participants will be randomly assigned to one of three groups: amoxicillin, metronidazole, or chlorhexidine. Participants will be assessed on Days 3 and 7 after extraction for the presence or absence of alveolar osteitis and postoperative pain. The study will determine whether there is a difference in the incidence of alveolar osteitis among the three treatment groups.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Patients aged 18 to 40 years.

Patients requiring non-surgical extraction of impacted or partially erupted mandibular third molars under local anesthesia.

Patients classified as American Society of Anesthesiologists (ASA) Physical Status I or II.

Patients who provide written informed consent to participate in the study.

Disqualifiers

Known allergy or drug hypersensitivity reaction to amoxicillin or metronidazole.

Patients presenting with active infection at the extraction site, evidenced by pus discharge.

Periodontally compromised (Grade 1) tooth.

Trial design

Design model

Parallel

Treatments tested in this trial

  • Amoxicillin

    Drug

    Amoxicillin will be administered as the prophylactic intervention to participants assigned to the amoxicillin group following lower third molar extraction. Placebo gel will be provided to maintain double blinding.

  • Metronidazole

    Drug

    Metronidazole will be administered as the prophylactic intervention to participants assigned to the metronidazole group following lower third molar extraction. Placebo gel will be provided to maintain double blinding.

  • Chlorhexidine

    Drug

    Chlorhexidine will be administered as the control intervention to participants assigned to the chlorhexidine group following lower third molar extraction. Placebo tablets will be provided to maintain double blinding.

Treatment groups

240 Participants
are divided into 3 treatment groups
Group A: Amoxicillin GroupExperimental treatment 1 intervention
Group B: Metronidazole GroupExperimental treatment 1 intervention
Group C: Chlorhexidine Control GroupActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Incidence of Alveolar Osteitis

Alveolar osteitis will be assessed as a binary outcome (yes/no) following lower third molar extraction. The incidence of alveolar osteitis will be compared among the amoxicillin, metronidazole, and chlorhexidine groups.

Time frame
Postoperative Day 3 and Day 7

Secondary outcomes

1

Postoperative Pain

Postoperative pain will be assessed using a Visual Analog Scale (VAS) with mild level (0-3), moderate level (3-7), and severe level(7-10) of pain following lower third molar extraction. Pain scores will be recorded and compared among the three study groups.

Time frame
Postoperative Day 3 and Day 7
2

Complications and Adverse Effects

Complications and adverse effects following lower third molar extraction and administration of the assigned intervention will be assessed and recorded.

Time frame
Postoperative Day 3 and Day 7

Other outcomes

Sponsors and contacts

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Khyber Medical University Peshawar

Lead sponsor

Khyber College of dentistry

Collaborator

Source ClinicalTrials.gov

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