Comparative Efficacy of IV Parecoxib vs Lidocaine in Reducing Propofol Injection Pain
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorOman Medical Speciality Board
About this trial
Propofol is the most popular IV anaesthetic agent used for induction, however one of its known side effects is causing pain on injection, the gold standard method in preventing this pain is using lidocaine prior to injecting propofol. multiple drugs have been investigated to reduce the aforementioned pain, however there has been no study comparing lidocaine to parecoxib, an NSAID.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adult patients, ≥18 years
ASA grading I-II
Patients undergoing elective surgical procedures across all surgical specialties.
Can speak Arabic or English
Disqualifiers
Difficulty in communicating.
Liver Cirrhosis patients
Renal failure or creatinine clearance (CrCl) ≤ 10umol/L,
Known Lidocaine, parecoxib and/or propofol allergy.
Trial design
Design model
Parallel
Treatments tested in this trial
Lidocaine, a local anaesthetic.
Drugit will be given as a pretreatment prior to injection of propofol, with a tourniquet applied.
Parecoxib 40mg
Drugatients in this group will receive IV parecoxib 40 mg (the standard full dose for an adult) diluted to a total volume of 5 mL with normal saline.
Treatment groups
30 Participants
are divided into 2 treatment groupsGroup A: ParecoxibActive comparator 1 intervention
Group B: LidocaineActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
incidence of pain on injecting propofol after receiving the treatment assigned.
Time frame
immediately after injection of 50 mg of propofol.Secondary outcomes
1
Severity of pain.
Measured Via Visual analogue scale for pain. The patient will be given 50 mg of propofol and asked if there is any pain, and the severity of the pain. The severity of pain will be graded on the scale between 1 and 10, 10 being the most severe in the scale, and 1 is the minimal pain experienced.
Time frame
immediately after injection of propofol.Locations
Sponsors and contacts
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Source ClinicalTrials.gov
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