1. To evaluate the efficacy and safety of topical resveratrol 1 % gel in treatment of melasma. 2. To compare between the efficacy of topical resveratrol 1 %gel versrs chemical peeling with TCA 20% in melasma.
• Age: 18-50 years old.
Pattern of melasma: Bilateral symmetrical facial melasma of any pattern.
Fitzpatrick skin phototypes: Types III, IV and V.
Pregnancy and lactation.
Patients taking oral contraceptive pills, hormonal replacement therapy or treatment for chronic illness at the time of the study or during the past 6 months.
Coexistence of diseases associated with hyperpigmentation such as Addison disease.
History of Scarring and keloid tendency
Parallel
resveratrol 1 % gel
Drugleft side of face the patient will be given resveratrol 1 % gel once daily at night (Home use ).
TCA20%
Drugleft side of face the patient will be given resveratrol 1 % gel once daily at night (homThee use ).
The primary outcome is the change in hemi-Melasma Area and Severity Index (hemi-MASI) score from baseline to one month after the end of treatment (follow-up)
assessed by clinical evaluation and photographic documentation. Clinical efficacy will be categorized as: Excellent response: \>75% decrease in hemi-MASI score Very good response: 50-75% decrease in hemi-MASI score Good response: 25-50% decrease in hemi-MASI score Poor response: \<25% decrease in hemi-MASI score
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