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Comparing Different Startegies of Positive Pressure Ventilation in Children

ConditionVentilation Therapy; Complications
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age1-5
SponsorBeni-Suef University

About this trial

The most basic modes of mechanical ventilation are volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV). VCV guarantees a target volume of ventilation using a constant flow, but may lead to high peak airway pressure (Ppeak) during the gas insufflation . In PCV mode, on the other hand,

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

age between 1 and 5 years.

patient scheduled for laparoscopic inguinal hernia repair.

American Society of Anesthesiologists classification of physical status of I-II.

Disqualifiers

cardiopulmonary disease.

severe hepatorenal dysfunction.

history of upper respiratory tract infection 2 weeks before the operation.

overweight [more than 20% of standard body weight].

Trial design

Design model

Sequential

Treatments tested in this trial

  • volume controlled ventilation

    Other intervention

    Pediatric patients in the VCV group (n= 30) received volume-controlled ventilation, target tidal volume was set at 7 mL/kg, with a respiratory rate of 16 breaths/min and a respiratory ratio of 1:2.

  • pressure controlled ventilation

    Other intervention

    Pediatric patients in the PCV group(n=30) received pressure-controlled ventilation. The initial parameters will be as follows: the peak inspiratory pressure (PIP) will set to provide a tidal volume of 7 ml/kg , respiratory rate will be 16 breaths/min, inspiratory to expiratory ratio was 1:2 with an upper limit of PIP of 20 cm H2O.

  • pressure controlled volume grantanteed ventilation

    Other intervention

    Pediatric patients in the PCV-VG group (n=30)will be conducted with pressure-controlled volume-guaranteed ventilation, target tidal volume will set at 7 mL/kg, with a respiratory rate of 16 breaths/min and a respiratory ratio of 1:2.

Treatment groups

78 Participants
are divided into 3 treatment groups
Group A: vCV groupActive comparator 1 intervention
Group B: PCV groupActive comparator 1 intervention
Group C: PCV-VG groupActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

(PIP)

peak inspiratory pressure

Time frame
within one hour
2

Pplat

plateau airway pressure

Time frame
within one hour
3

(Cdyn)

pulmonary dynamic compliance

Time frame
within one hour
4

(RAW

airway resistance

Time frame
within one hour

Secondary outcomes

1

(MAP)

mean arterial pressure

Time frame
within one hour
2

(HR)

heart rate

Time frame
within one hour
3

postoperative respiratory adverse events

cough, hoarseness, sore throat, hypoxemia, laryngospasm, bronchospasm.

Time frame
within 24 hour

Other outcomes

Locations

1

Map coordinates are unavailable for these locations. Locations are shown below instead.

Benisuef university hospitalRecruiting BenisuefEgyptEgypt

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Beni-Suef University

Lead sponsor

Source ClinicalTrials.gov
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