Comparing the efficacy of superhigh-flux dialyzer with high-flux dialyzer in ESKD patient who have sepsis to improve mortality and sepsis outcome, an open label randomized control trial.
ESKD patients who have sepsis condition with high interleukin-6 (IL-6 > 50 pg/ml)
Patients who needed dialysis with continuous kidney replacement therapy, vulnerable patient, include pregnant woman, patient who expected to pass away within the 24 hours.
Patients who have the history of allergic dialyzer reaction to dialyzer which used in this trial.
Parallel
Super High-flux dialyzer (Elisio 19HDx)
DeviceDialysis with Super High-flux dialyzer for intervention group
High-flux dialyzer (Elisio 19H)
DeviceDialysis with High-flux dialyzer for control group
Comparing the reduction of all cause death at 28 days
Comparing the efficacy to reduce all cause death at 28 days between Super High-flux dialyzer with High-flux dialyzer in ESKD with sepsis
Comparing the difference of blood level of IL-6, ESR, CRP and albumin, before and after of the first dialysis session, in each group.
The duration of inotrope weaning
The duration of hospitalization
Ventilator free days
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