Comparing Thoracolumbar Interfascial and Quadro Iliac Plane Blocks on Postoperative Opioid Use Following Lumbar Microsurgery

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorMedipol University

About this trial

Lumbar microdiscectomy is a commonly used surgical procedure for treating herniated discs. Effective postoperative analgesia is crucial for early mobilization and functional recovery. Uncontrolled postoperative pain can delay recovery, increase the risk of opioid dependence, and lead to respiratory complications.

Although opioid analgesics effectively reduce pain, they can cause side effects such as nausea, vomiting, respiratory depression, and dependency. Therefore, non-opioid analgesic methods are preferred for patient safety and comfort. Recently, regional anesthesia techniques such as the Thoracolumbar Interfascial Plane (TLIP) block and the Quadro Iliac Plane Block have been introduced for postoperative pain management in lumbar surgeries. However, there are not enough studies comparing the superiority of these two methods.

Study Objective: The primary aim of this study is to evaluate the effects of ultrasound-guided TLIP and Quadro Iliac Plane Blocks on postoperative opioid consumption after lumbar microsurgery. The secondary aim is to compare opioid-related side effects (such as nausea, vomiting, respiratory depression, etc.) and postoperative NRS pain scores between the groups.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients aged 18 to 80 years

American Society of Anesthesiologists (ASA) physical status I to III

scheduled for lumbar microdiscectomy surgery

Disqualifiers

Known allergy to local anesthetics

Any other significant drug allergies related to the study interventions

Pregnancy

Pre-existing psychiatric or neurological disorders

Trial design

Design model

Parallel

Treatments tested in this trial

  • Standard Analgesia (No Block)

    Procedure/Surgery

    Participants receive standard perioperative analgesia (including intravenous paracetamol/tramadol), but no additional regional block is applied.

  • Thoracolumbar Interfascial Plane (TLIP) Block

    Procedure/Surgery

    In addition to standard perioperative analgesia, a TLIP block is performed under sterile conditions and ultrasound guidance, after the surgical procedure is completed but before the patient is awakened. A total of 20 mL of 0.25% bupivacaine is injected into the thoracolumbar fascial plane, and spread is confirmed via ultrasound.

  • Quadro Iliac Plane Block

    Procedure/Surgery

    In addition to standard perioperative analgesia, a Quadro Iliac Plane Block is performed under sterile conditions and ultrasound guidance, after the surgical procedure is completed but before the patient is awakened. A total of 20 mL of 0.25% bupivacaine is injected into the quadro iliac plane at the level of the iliac crest, and spread is confirmed via ultrasound.

Treatment groups

90 Participants
are divided into 3 treatment groups
Group A: No Block (Control Group)Active comparator 1 intervention
Group B: TLIP BlockExperimental treatment 1 intervention
Group C: Quadro Iliac Plane BlockExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

tramadol consumption

Total tramadol consumption (mg) in the first 24 hours after surgery.

Time frame
first 24 hours after the operation

Secondary outcomes

1

NRS (Numerical Rating Scale) pain scores

NRS (0-10) scores will be measured at 3, 6, 12, 18, and 24 hours during both rest and mobilization in the postoperative period.

Time frame
first 24 hours after the operation
2

opioid-related side effects (such as nausea, vomiting, respiratory depression)

The incidence of opioid-related side effects (e.g., nausea, vomiting, respiratory depression) will be recorded and compared between groups.

Time frame
first 24 hours after the operation

Other outcomes

Sponsors and contacts

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