Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment

ConditionsPeriapical Lesion Periapical Periodontitis

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-65

SponsorFaiz ur rahman

About this trial

This study compares two commonly used intracanal medicaments-Triple Antibiotic Paste and Calcium Hydroxide-in patients with infected single-rooted teeth. The purpose is to determine which medicament promotes faster healing of periapical lesions after root canal treatment by measuring reduction in lesion size and improvement in bone density over 3, 6, and 12 months.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Systemically healthy adult patients between 18 and 65 years of age.

Disqualifiers

None

Trial design

Design model

Parallel

Treatments tested in this trial

Triple Antibiotic Paste
Drug
Intracanal medicament paste composed of Ciprofloxacin, Metronidazole, and Minocycline. Placed in the root canal for several weeks.
Calcium Hydroxide (Ca(OH)2)
Drug
Standard intracanal medicament with high pH, used for its antibacterial and tissue-stimulating properties. Placed in the root canal for several weeks

Treatment groups

62 Participants

are divided into 2 treatment groups

Group A: Triple Antibiotic Paste (TAP)Experimental treatment 2 interventions

Group B: Calcium Hydroxide GroupActive comparator 2 interventions

Trial outcomes

Primary outcomes

Change in Periapical Lesion Area

Percentage reduction in the area (mm²) of the periapical radiolucency from baseline, as measured on standardized periapical radiographs or CBCT scans.

Time frame

Baseline, 3 months, 6 months, 12 months

Secondary outcomes

Change in Periapical Bone Density Score

Improvement in a standardized bone density score or grayscale value of the periapical bone from baseline

Time frame

Baseline, 3 months, 6 months, 12 months

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Faiz ur rahman

Lead sponsor

College of Physicians and Surgeons Pakistan

Sponsor institution

Source ClinicalTrials.gov

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