Comparison of an Acceleromyography- and Electromyography-based Neuromuscular Monitor With TOF-Watch ® Monitor

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-90
SponsorHuazhong University of Science and Technology

About this trial

A quantitative neuromuscular monitoring device is desirable to titrate the depth of neuromuscular block (NMB) during a procedure, and to prevent residual effects after removal of the endotracheal tube. Unfortunately, the most widely used monitoring technique acceleromyography (AMG) typically implies a series of cumbersome installation and calibration procedures that frequently precludes correct use of these devices in clinical practice. Electromyography (EMG) has recently attracted a lot of attention as an alternative strategy to compensate for the deficiency of AMG-based neuromuscular monitors. Nowadays, a new technology that allows for the simultaneous acquisition of EMG and AMG signals is commercially available. Although its reliability has been rapidly accepted in Physical Medicine and Rehabilitation, the use of the technique in neuromuscular monitoring has never been reported. The aim of the present study is to assess the validity of the new device for estimating the neuromuscular block by comparing with TOF Watch®-SX, which is the most widely accepted AMG-based neuromuscular monitor that has been practiced in the clinical arena for decades.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age less than 18 yr

American Society of Anesthesiologists Physical Status I to III

Elective surgery requiring muscle relaxation

Patients participated voluntarily and signed informed consent

Disqualifiers

Patients with known neuromuscular disorder

Stroke

Patients with a history of allergic reaction toneuromuscular blocking agents

Use of medications that might interfere with neuromuscular transmission

Trial population

Patients who need to be treated surgically under general anesthesia and are going to receive neuromuscular blocking agents.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • TOF-Watch®;DELSYS® Wireless surface EMG

    Device

    TOF-Watch® is the most widely accepted AMG-based neuromuscular monitor; and DELSYS® Wireless surface EMG is a new technology that allows for the simultaneous acquisition of EMG and AMG signals in a wireless manner.

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

Assessing the correlation between the train-of-four (TOF) obtained from the 2 devices

Time frame
Perioperative data
2

Assessing the correlation between the posttetanic count (PTC) obtained from the 2 devices

Time frame
Perioperative data

Secondary outcomes

1

Screening for eligible individual signal sources from the multiplex information of the new technology for improving neuromuscular monitoring

Time frame
Perioperative data

Other outcomes

Sponsors and contacts

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