Pain, edema and trismus are the most frequent postoperative sequelae to surgical removal of impacted teeth, all of are due to the local inflammatory response.
Use of corticosteroids decrease tissue mediators of inflammation and reduce edema.
Use of trypsin-chymotrypsin elaborates the enzymes esterase in blood plasma that inhibits inflammation by hydrolytic degradation of the inflammatory peptides.
Clinically healthy patients (ASA I) patient free of any systemic diseases that could interfere with wound healing or surgical operation.
Free of any recent anti-inflammatory drug intake or being under long term treatment with medicaments that will obscure the assessment of the inflammatory response as NSAIDs, steroids, or antihistamines
Free from allergy to the drugs used in the study
Patients requiring surgical removal of the mandibular impacted third molar
Patients who are ASA II to ASA VI.
Patients already on corticosteroids through any route.
Patients with known allergy to any drugs.
Pregnant and lactating females
Parallel
Dexamethasone
Druglocal infiltration
Chymotrypsin
Drugorally given
comparison of clinical efficacy of submucosal dexamethasone and oral trypsin-chymotrypsin for reduction of postoperative sequelae after lower third molar surgery
previous study had shown submucosal dexamethasone is more effective than oral trypsin chymotrypsin
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