Comparison of Microglial Activation in Severe Asthma and Healthy Controls
ConditionAsthma
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorUniversity of Wisconsin, Madison
About this trial
The goal of this clinical trial is to learn about how asthma influences brain function. The main questions it aims to answer are:
* How airway inflammation in asthma affects the brain; and, * Whether airway inflammation in asthma is related to symptoms of depression and anxiety
Over the course of 3 visits, participants will:
* Complete questionnaires * Complete computer tasks * Undergo allergy skin test and breathing tests * Give two blood samples * Give a sputum sample * Complete brain imaging scans
Researchers will compare results between participants with asthma, and participants who do not have asthma.
Eligibility criteria
Qualifiers
Ability to understand and the willingness to sign a written informed consent document
Individuals with no health concerns that might affect the outcome of the study
Age 18-75 years of age
Ability to tolerate a simulated MRI brain scanning session
Disqualifiers
Current smoker (defined as more than 0.5 pack per week for the past 6 months and any smoking within two weeks of study procedures) or has a smoking history exceeding 5 pack years within the last 10 years
Currently receiving allergen immunotherapy unless on stable dose.
Use of psychotropic medication that might affect function of neurocircuitry implicated in our hypotheses (at the discretion of the PI/Co-I)
Inability to hold medications detailed in the medication hold schedule
Trial design
Treatments tested in this trial
- PET/MRI using [18F]FEPPA tracer
Treatment groups
100 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of Wisconsin, Madison
Lead sponsor
National Institute on Aging (NIA)
Collaborator
Source ClinicalTrials.gov