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Comparison of MIST With PRF and GBT With PRF in the Treatment of Intrabony Periodontal Defect. A Prospective RCT

ConditionIntrabony Periodontal Defect
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorSemmelweis University

About this trial

The aim is to evaluate in a prospective, randomized, controlled clinical study the healing of a MIST procedure combined with PRF, or GBT combined with PRF. Clinical, radiological evaluation of the regenerative surgical method and the GBT non-surgical therapy in solitaire deep intrabony periodontal defect.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

solitaire intrabony periodontal defect at least 4 mm

Disqualifiers

Periodontitis with intrabony defect (Intrabony component ≥ 4mm, defect radiological angulation > 25°,

The patient is able to comply with the study -related procedures (i.e. good level of oral hygiene, follow-up procedures).

Patients must not be heavy smokers (<5 cigarettes/day).

furcation involvement

Trial design

Design model

Parallel

Treatments tested in this trial

  • Guided biofilm therapy

    Device

    Use of Airflow Plus powder subgingivally on teeth with deep periodeontal pockets

  • Platelet Rich Fibrin

    Procedure/Surgery

    Pack Platelet Rich Fibrin chops into the intrabony periodontla defect

  • Minimally Invasive Surgical Technique

    Procedure/Surgery

    Periodontal intrabony defect is treated by minimally invasive surgical intervention

Treatment groups

36 Participants
are divided into 3 treatment groups
Group A: Test 1 Guided biofilm therapy in combinaton with Platelet rich fibrineExperimental treatment 2 interventions
Group B: Test 2 Minimally invasive surgical therapy in combination with Platelet rich fibrineExperimental treatment 2 interventions
Group C: Control groupActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Intrabony fill

The change of the intrabony component compared to the initial intrabony defect depth (in percentage), which is measured on standardised individualised x-ray.

Time frame
6 months

Secondary outcomes

1

PPD

Pocket probing depth measured clinically by calibrated periodontal probe (UNC 15)

Time frame
6 months
2

GR

Gingival recession measured clinically by calibrated periodontal probe (UNC 15)

Time frame
6 months
3

CAL

Clinical attachment level measured clinically by calibrated periodontal probe (UNC 15)

Time frame
6 months

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Semmelweis University

Lead sponsor

Source ClinicalTrials.gov
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