Comparison of Root Canal Desinfection Protocols
ConditionPeriapical Periodontitis
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorState University of New York at Buffalo
About this trial
Evaluate and compare the disinfecting efficacy of two supplementary antimicrobial protocols in teeth with apical periodontitis
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adult patients able to give informed consent and willing/able to comply with study procedures and follow-up.
Molar teeth indicated for endodontic treatment.
Teeth with intact pulp-chamber walls (no extensive coronal destruction).
Necrotic pulp confirmed by pulp testing.
Disqualifiers
Immature teeth
Teeth with calcified or obliterated canals
Teeth with extensive coronal destruction
Teeth with previous endodontic treatment
Trial design
Design model
Parallel
Treatments tested in this trial
Desinfection device
DeviceDesinfection protocol with (LAI): Er,Cr:YSGG laser (2780 nm) delivered with a radial-firing tip.
Analytical microbiological methods
DeviceEndocator: Measures ATP levels (Endoscore and RLU) to rapidly assess bacterial load in less than one minute.
Treatment groups
50 Participants
are divided into 2 treatment groupsGroup A: Desinfection deviceActive comparator 1 intervention
Group B: Analytical microbiological methodActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Reduction of bacteria in the root canal system
Evaluation of the effectiveness of different irrigation activation devices by assessing bacterial reduction in the root canal system. ATP levels will be measured (Endoscore and RLU values) to provide a rapid assessment of bacterial load in less than one minute. Subsequently, bacterial reduction will be confirmed by quantitative polymerase chain reaction (qPCR) analysis
Time frame
Immediately after the irrigation activation procedure, ATP levels will be measured, and qPCR analysis will be performed at the end of the study, once all samples have been collected.Sponsors and contacts
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Source ClinicalTrials.gov