Comparison of Sevoflurane and Propofol on ANI
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age19+
SponsorPusan National University Yangsan Hospital
About this trial
The goal of this clinical trial is to compare the effect of sevoflurane and propofol on analgesia nociception index(ANI) in patients undergoing general anesthesia. The main question it aims to answer is whether propofol anesthesia results in lesser ANI change to a nociceptive stimulation compared to sevoflurane.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
American society of anesthesiologists physical status class I or II
Disqualifiers
history of drugs that can affect the central nervous system and autonomic nervous system, such as anticholinergics, betablockers, antidepressants..etc.
history of allergic reaction to sevoflurane and/or propofol
history of and/or family history of malignant hyperthermia
neurodegenerative disorder
Trial design
Design model
Parallel
Treatments tested in this trial
propofol
Drugpropofol anesthesia
Sevoflurane
Drugsevoflurane anesthesia
Treatment groups
30 Participants
are divided into 2 treatment groupsGroup A: SevofluraneOther 1 intervention
Group B: PropofolOther 1 intervention
Trial outcomes
Primary outcomes
1
analgesia nociception index change
analgesia nociception index value 1-minute before tetanic stimulation and 1-minute after tetanic stimulation
Time frame
During anesthesia periodSecondary outcomes
1
Hemodynamic change
Blood pressure change 1 minute before tetanic stimuation and 1 minute after tetanic stimulation
Time frame
During anesthesia period2
Hemodynamic change
Heart rate change before 1-minute before nociceptive stimuli and 1-minute after nociceptive stimuli
Time frame
During anesthesia periodLocations
Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: