Comparison of the Efficacy of Celiac Plexus Blockade, ESP and Lidocaine Infusion Under OFA

ConditionsRegional Anaesthesia Anesthesia and Analgesia

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18-75

SponsorJagiellonian University

About this trial

Modern anesthesiology, in search of alternatives to opioid-based pain management, is turning to low-opioid and non-opioid protocols. Replacing opioids with non-opioid analgesics, co-analgesics, and regional and local anesthesia techniques allows avoiding the adverse effects of opioids while maintaining satisfactory analgesia. This is of particular importance in bariatric surgery, where reducing the incidence of respiratory depression, sedation, opioid hyperalgesia, and postoperative nausea and vomiting is a priority. Standard non-opioid anesthesia (OFA) includes ketamine, lidocaine, and dexmedetomidine infusions, while regional techniques additionally reduce the need for analgesics. Despite the widespread use of these methods, there is no clear data on the superiority of any of them in bariatric procedures.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients over 18 years who underwent laparoscopic bariatric surgery

Must be able to sign agreement for study

Disqualifiers

Patients with a history of allergic reactions to drugs

Patients with a history of drug addiction

Patients with chronic pain who require analgesics

History of hospitalization for psychiatric disorders

Trial design

Design model

Parallel

Treatments tested in this trial

Celiac Plexus Block
Drug
During general anesthesia, a celiac plexus block will be performed intraoperatively (20 ml of 0.5% ropivacaine). The patient will not feel discomfort due to general anesthesia.
ESP block
Drug
Before the procedure, a block of the erector spinae (ESP) compartment will be performed with approximately 20 ml of 0.25% ropivacaine at the Th4 level. The patient will be informed about the possibility of short-term discomfort if the block is performed before full induction of anesthesia.
Lidacaine
Drug
Instead of a regional block, an intravenous infusion of lidocaine will be used.

Treatment groups

300 Participants

are divided into 3 treatment groups

Group A: Erector Spinal BLockExperimental treatment 1 intervention

Group B: Celiac Plexus BlockExperimental treatment 1 intervention

Group C: Lidocaine IVPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

Life quality

Every patient will do OR-15

Time frame

1 day

Secondary outcomes

posoperative pain

NRS score after operation from 0 to 10

Time frame

1 day

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Jagiellonian University

Lead sponsor

Source ClinicalTrials.gov

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