Comparison of the Metabolomic Effects of Sevoflurane and Desflurane Anesthesia in Laparoscopic Cholecystectomy
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorHarran University
About this trial
Analytical techniques used in metabolomic studies include nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). The study will involve comparing the metabolomic profiles of patients receiving sevoflurane and desflurane during surgery to identify any differences in metabolic pathways affected by the two anaesthetic techniques. Metabolomic profiles are generated using spectroscopic and spectrometric techniques such as high-field NMR and MS, as well as separation techniques.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients undergoing laparoscopic cholecystectomy surgery who have no active infection, Body mass index (BMI)<35, Aged 18-65, ASA I-II, and who agree to participate in the study
Disqualifiers
Individuals over 65 years of age ASA 3-4 patients Individuals with a body mass index (BMI) >35 Smokers
Trial design
Design model
Parallel
Treatments tested in this trial
Sevoflurane
Procedure/SurgeryThis group will be operated on under sevoflurane.
Desflurane
Procedure/SurgeryThis group will be operated on under desflurane.
Treatment groups
80 Participants
are divided into 2 treatment groupsGroup A: sevoflurane groupActive comparator 1 intervention
Group B: desflurane groupActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
amino acid metabolism
Time frame
12 weeks2
Our primary outcome measure will be the effect of both inhalation anaesthetics on amino acid metabolism.
Time frame
12 weeksLocations
Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: