Health TrialsbyHealthPanel

Comparison of Transcutaneous and Blood CO₂ Measurement in Critically Ill Children

ConditionRespiratory Insufficiency in Children
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age1-18
SponsorBrno University Hospital

About this trial

Transcutaneous capnometry (tPCO₂) is a non-invasive method for continuous monitoring of ventilation status. In pediatric intensive care patients, it may reduce the need for repeated arterial or arterialized blood sampling. However, the accuracy of tPCO₂ may be influenced by factors such as peripheral perfusion, skin temperature, and vasopressor therapy. This prospective observational study compares transcutaneous carbon dioxide measurements with arterialized or arterial blood gas PaCO₂ values in children with respiratory insufficiency, including a subgroup receiving vasopressor support.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age 1-18 years

Diagnosis of respiratory insufficiency or impaired peripheral perfusion

Expected need for more than one arterialized capillary or arterial blood gas sample

Admission to PICU

Disqualifiers

Repeated failure of sensor adhesion

Hypothermia < 35 °C

Time difference > ±5 minutes between tPCO₂ and blood sampling

Large tPCO₂ variability (> ±1 kPa) in 15 minutes preceding blood sampling

Trial population

Critically ill pediatric patients admitted to a tertiary PICU with respiratory insufficiency or circulatory compromise.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Partial CO2 difference

Agreement between transcutaneous CO₂ (tPCO₂) and arterialized or arterial PaCO₂ assessed using Bland-Altman analysis (bias, SD, 95% limits of agreement).

Time frame
periprocedural

Secondary outcomes

1

Proportion of pCO2

Proportion of tPCO₂ values within ±1 kPa of PaCO₂

Time frame
periprocedural
2

Partial O2

Agreement between transcutaneous oxygen (tPO₂) and PaO₂

Time frame
periprocedural
3

Vassopressor use

Subgroup analysis based on presence of vasopressor support

Time frame
periprocedural

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Brno University Hospital

Lead sponsor

Source ClinicalTrials.gov
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