Components of Mechanical Power on the Functional Lung in ARDS

ConditionRespiratory Distress Syndrome (RDS)

Trial statusNot yet recruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorRamos Mejía Hospital

About this trial

Mechanical power (MP) is a composite variable that integrates static and dynamic respiratory parameters and has been associated with ventilator-induced lung injury (VILI). MP is predominantly delivered to the reduced functional lung size, commonly referred to as the "baby lung" (BL). Functional lung size, in turn, is closely related to respiratory system compliance (Crs). Previous studies have demonstrated an association between MP normalized to compliance (MP/Crs) and mortality. Moreover, evidence suggests that VILI associated with MP/Crs results primarily from the combined effect of its components rather than from any single component in isolation.

The objective of this study is to evaluate both the overall and the relative contribution of each component of mechanical power, normalized to compliance (MP/Crs), to in-hospital mortality in patients with acute respiratory distress syndrome (ARDS).

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients ≥ 18 years

Diagnosis of acute respiratory distress syndrome

Receiving invasive mechanical ventilation (volume control mode) for at least 48 consecutive hours.

Disqualifiers

Patients spontaneously breathing

Patients under non-invasive support therapies

Patients receiving ventilation through a tracheostomy cannula at any time during the first 48 h

Patients that receiving pressure-controlled ventilation or any modality other than volume-controlled

Trial population

Patients ≥ 18 years with acute respiratory distress syndrome receiving invasive mechanical ventilation for at least 48 consecutive hours

Trial design

Design model

Cohort

Time perspective

Retrospective

Treatments tested in this trial

monitoring of clinical and ventilatory variables
Other intervention
Monitoring clinical data

Treatment groups

184 Participants

are divided into 1 treatment group

Group A: Survivors1 intervention

Trial outcomes

Primary outcomes

Mechanical Power normalized to compliance (MP/Crs) and in-hospital mortality

Mechanical Power (MP) will be calculated using ventilator-derived parameters (tidal volume in mL, driving pressure in cmH₂O, inspiratory flow in L/s, and respiratory rate in breaths/min). This value will then be normalized to respiratory system compliance (Crs, in mL/cmH₂O) to obtain MP/Crs. The reported outcome will be a single aggregated measure, expressed in Joules per minute cmH2O (J/min/cmH2O), assessed on the third day of mechanical ventilation.

Time frame

MP/Crs: day 3. Mortality: from enrollment until hospital discharge.

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Ramos Mejía Hospital

Lead sponsor

Universidad de la Republica

Collaborator

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: