Hair analysis in pediatric cannabis intoxication is limited by possible sudoral self-contamination, especially in young children due to hair porosity. However, adult studies show no THC-COOH in sweat, challenging this hypothesis. THC-COOH presence in sweat has to this day never been studied in young children. Its absence would help assess the reliability of hair testing for prior exposure. Thus, our main objective is to describe whether THC-COOH can be detected in sweat following cannabis intoxication using gold standard techniques.
Child admitted to the Specialized Emergency Pole (POSU) and pediatric medico-surgical emergencies for acute cannabis intoxication.
Child older than 3 months and younger than 3 years.
Holders of parental authority, affiliated with or beneficiaries of a social security system.
History of cannabis intoxication identified during the interview and/or consultation of the medical record.
Contraindication to sweat sampling (described in section 6).
Absence of hair and/or hair length < 1 cm at the time of inclusion.
Ongoing breastfeeding (exclusive and mixed).
Single group
sudoral and hairing sampling
Other interventionSweat sampling using the "sweat test" method, performed after skin stimulation with pilocarpine and a low electrical stimulation. Hair sampling during the follow-up consultation. Sweat, and capillary assays of THC and its main metabolites
Acide 11-nor-9-carboxy-THC (THC-COOH) concentrations in sweat collected during the first 24 hours following emergency admission.
concentration measured in sudoral sample (in µg/l)
Tétrahydrocannabinol (THC), 11-hydroxy-tétrahydrocannabinol (OH-THC) and THC-COOH measured in blood and sweat collected during the first 24 hours following emergency admission.
Determination whether blood and sweat THC, OH-THC and THC-COOH concentrations, if present, are correlated following intoxication (in µg/l)
THC, OH-THC and THC-COOH measured in two hair samples.
Describing the evolution of THC, OH-THC and THC-COOH hair concentrations in young children (in µg/l)
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University Hospital, Toulouse
Lead sponsor
University Hospital, Limoges
Collaborator
