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Continuous Renal Replacement Therapy, Impact on Intensive Care Unit Length of Stay

ConditionsAKI - Acute Kidney InjuryCritical Illness
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorKarolinska Institutet

About this trial

This large national cohort study, including over 500,000 patients, where around 5% are treated with continuous renal replacement therapy (CRRT) , aims to evaluate the association between time to initiation of CRRT and intensive care unit (ICU) length of stay (LOS).

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients with critical illness

Admitted to Swedish ICUs from 2010-2023

Adult (18 years or older)

Disqualifiers

None

Trial population

All adult critically ill patients in Swedish ICUs from 2010-2023, with- and without the need of CRRT forms this cohort. Within the cohort, a nested case-control type of study can be performed. Two groups: Group 1: Patients with CRRT initiation time less than 30 hours (early CRRT) Group 2: Patients with CRRT initiation time 30 hours or more (late CRRT)

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • continuous renal replacement therapy

    Device

    We are evaluting early vs late initiation of CRRT

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

Intensive care unit (ICU) length of stay (LOS) measured in hours

Hours from baseline, i.e. ICU admission (time=0) to ICU discharge (time=0+hours in ICU)

Time frame
ICU LOS during the study period, from admission to discharge, average 168 hours (one week)

Secondary outcomes

1

Mortality

Days from baseline, i.e. ICU admission to 30, 90,180 and 365 day mortality

Time frame
ONE-YEAR Mortality post admission
2

Mechanical ventilation

Hours from baseline, i.e. start of ventilation (time=0) until end of ventilation, hours

Time frame
Time on mechanical ventilation during the study period, average one week, but up to ICU discharge

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Karolinska Institutet

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: