Continuous Theta Burst Stimulation for Generalized Anxiety Disorder
ConditionGeneralized Anxiety Disorder
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorMilitary Hospital 175
About this trial
This randomized clinical trial evaluates the effectiveness of continuous theta burst stimulation (cTBS) combined with background pharmacotherapy in patients with generalized anxiety disorder. Participants will be randomly assigned to receive cTBS targeting either the right posterior parietal cortex or the right dorsolateral prefrontal cortex. The study will compare changes in anxiety symptoms between the two treatment strategies and will also assess quality of life, sleep, cognitive function, electroencephalographic measures, and transcranial magnetic stimulation-electroencephalography measures.
Eligibility criteria
Qualifiers
Adults aged 18 to 59 years.
Diagnosis of generalized anxiety disorder (GAD; ICD-10 F41.1) according to DSM-5 diagnostic criteria.
Hamilton Anxiety Rating Scale (HAM-A) total score >18 at screening.
Able to understand the study procedures and provide written informed consent.
Disqualifiers
History of epilepsy or seizures.
Presence of metal or implanted electronic devices that are contraindications to transcranial magnetic stimulation (TMS), including relevant intracranial metallic implants or cardiac pacemakers.
Pregnancy.
Acute psychotic symptoms or high suicide risk.
Trial design
Treatments tested in this trial
- Continuous Theta Burst Stimulation of the Right Posterior Parietal Cortex
- Continuous Theta Burst Stimulation of the Right Dorsolateral Prefrontal Cortex
Treatment groups
40 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov