INDUCT-Multi is a multicenter randomized trial investigating whether continuous, compared to bolus, administration of norepinephrine during induction of general anesthesia reduces postinduction hypotension in high-risk non-cardiac surgery patients.
Age ≥65 years
ASA physical status III or IV
Chronic arterial hypertension
Diabetes mellitus requiring medication
Pregnancy
Cardiac arrhythmia
History of intracranial hemorrhage or intracranial aneurysm
Clinical indication for continuous norepinephrine infusion during induction of general anesthesia (e.g., severe aortic valve stenosis, coronary artery disease, or heart failure)
Parallel
Continuous Norepinephrine Administration
Procedure/SurgeryIn patients assigned to continuous administration of norepinephrine, a syringe infusion pump will be prepared and connected to a peripheral or central venous catheter. The responsible anesthesiologist will start the norepinephrine infusion and adjust the infusion rate as necessary and may administer additional norepinephrine boluses via the syringe infusion pump if required.
Area under a mean arterial pressure (MAP) of 65 mmHg (mmHg x min)
Area under a MAP of 60 mmHg (mmHg x min)
Area under a MAP of 50 mmHg (mmHg x min)
Area under a MAP of 40 mmHg (mmHg x min)
Area above a MAP of 100 mmHg (mmHg x min)
Acute kidney injury
Nonfatal cardiac arrest
Myocardial infarction
Death
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