Contribution of Corticospinal and Reticulospinal Mechanisms to Neural Adaptations Induced by Muscle Strengthening of Healthy Adults

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-40
SponsorInstitut National de la Santé Et de la Recherche Médicale, France

About this trial

This controlled trial aims to investigate the neural adaptations induced by a 4-week resistance training program targeting the triceps surae muscles. Specifically, the study will examine the contribution of the corticospinal and reticulospinal pathways to the nervous adaptations associated with resistance training. It will give us more information about the nervous pathways mediating adaptations following this type of training. The main question it aims to answer is: What is the contribution of the cortico- and reticulospinal tracts to the nervous adaptations following a resistance training program?

Participants will take part to a resistance training program of the triceps surae for 4 weeks. They will undergo assessments of corticospinal and reticulospinal excitability before and after the training intervention to determine changes in neural pathways

The findings will improve our understanding of the neural mechanisms underlying strength gains following resistance training.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Male or female participants aged 18 to 40 years

Willing and able to provide written informed consent

No regular participation (>1 session per week) in resistance training aimed at increasing maximal strength

Affiliated with, or beneficiary of, a social security system

Disqualifiers

Personal or family history of epilepsy

Conditions associated with a significantly reduced seizure threshold, including sleep deprivation, extreme fatigue, or jet lag

Use of medications or substances known to lower the seizure threshold

Use of medications that may influence neurophysiological measures (e.g., neuroleptics, anxiolytics, antidepressants, anticonvulsants)

Trial design

Design model

Single group

Treatments tested in this trial

  • Resistance training

    Behavioral

    Participants will complete a 4-week resistance training program targeting the triceps sure muscles (3 sessions per week).

Treatment groups

22 Participants
are divided into 1 treatment group
Group A: Resistance training groupExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

the change in maximum force achieved during a maximal voluntary contraction (MVC) of plantar flexion (the primary action of the triceps surae muscles).

The maximum force, achieved during a maximal voluntary contraction (MVC), will be recorded using an isokinetic ergometer (Biodex Medical Systems Inc., Shirley, NY, USA).

Time frame
At baseline (before the first exercise session) and immediately after completion of the exercise sessions

Secondary outcomes

1

The changes in the amplitude of electrophysiological responses evoked by magnetic or electrical stimulation at different levels of the neuromuscular system (cortical, thoracic, peripheral nerve).

Electrophysiological responses will be recorded using surface electromyography (sEMG), with electromyography electrodes (Contrôle Graphique Medical, Brie-Compte-Robert, France) placed on the muscle surface of the muscles under study. The following techniques will be used to elicit these responses, whether or not they are conditioned by auditory stimulation: intense auditory stimulation at 115 dB (SSI) coupled with a visual stimulus (i.e., the illumination of a red light-emitting diode, LED); non-intense auditory stimulation at 70 dB (SS) coupled with the illumination of a red LED; the illumination of the red LED without any sound stimulation (V).

Time frame
During intervention

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

This trial is not recruiting at the moment. You can still explore other options: