The purpose of this study is to assess the effect of pseudoexfoliation syndrome on corneal biomechanics, optical clarity of the cornea, and anterior segment structural features.
age 60-80 years.
unilateral or bilateral pseudophakia (cataract surgery undergone at Papageorgiou General Hospital, Thessaloniki, Greece).
open anterior chamber angle (grade > 2, van Herick method).
History of intraocular surgery other than uncomplicated cataract surgery (phakoemulsification).
Cataract surgery within the last 3 months.
History of ocular trauma.
Use of contact lenses.
Participants will be selected from patients who consult at the outpatient clinic of the 2nd Department of Ophthalmology, General Hospital Papageorgiou, Thessaloniki, Greece.
Case-control
Cross-sectional
Pentacam-AXL
DevicePentacam-AXL (Oculus, Wetzlar, Germany)
HD Analyzer
DeviceHD Analyzer (Visiometrics, Terassa, Spain, Keeler)
Corvis ST
DeviceCorvis ST (Oculus, Germany)
OCT-A Angiovue
DeviceOCT-A Angiovue (Optovue, Inc., Fremont, California, USA)
IOLMaster V.5.4
DeviceIOLMaster V.5.4 (Carl Zeiss., Meditec)
Topcon SP-1P
DeviceTopcon SP-1P (Topcon Medical Inc., Tokyo, Japan)
BCVA (ETDRS), Slit lamp examination, Goldmann Applanation Tonometry, Fundus examination
Other interventionBCVA (ETDRS), Slit lamp examination, Goldmann Applanation Tonometry, Fundus Examination
Corneal optical density assessed by backscatter measurement
Corneal optical density assessed by backscatter measurement (COD, corneal optical density) using Pentacam AXL (Oculus, Wetzlar, Germany)
Corneal optical density assessed by forward-scatter measurement
Corneal optical density assessed by forward-scatter measurement (OSI, objective scatter index) using HD Analyzer (Visiometrics, Terassa, Spain, Keeler)
Corneal biomechanics using Corvis Scheimpflug Technology
The main biomechanical parameter of the Corvis ST : DA (deformation amplitude). DA quantifies how the cornea deforms in response to an air puff and helps evaluate corneal stiffness and elasticity.
Optical quality measured by HD-analyzer : Strehl ratio
Specific measurement variable: Total score of Strehl ratio; Value \[no dimension\];
Optical quality measured by HD-analyzer : MTF cut-off
Specific measurement variable: Total score of Modulation transfer function (MTF) cut-off; Value \[c/deg\];
Corneal biomechanics using Corvis Scheimpflug Technology : velocity
Velocity during the first and the second applanation of the cornea, measured using Corvis ST \[m/s\]
The level of agreement between the two optical density indicators (OSI, COD) after standardization
The level of agreement between the two optical density indicators : objective scatter index (OSI), corneal optical density (COD) after standardization. Value \[no dimension\]
Anterior chamber depth (mm)
Anterior chamber depth (mm)
Endothelial cell density (cells/mm2)
Endothelial cell density (cells/mm2)
Corneal topography (D)
Corneal topography (D)
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Aristotle University Of Thessaloniki
Lead sponsor
Papageorgiou General Hospital
Collaborator
