The goal of this observational study is to learn about the factors which determine how well ventricular tachycardia (VT) is tolerated. The main questions it aims to answer are:
1. What impact does coronary artery disease have on the ability for a patient to tolerate VT? 2. Does treatment of coronary artery disease with stents improve the tolerability of VT?
Participants who are undergoing a clinically indicated coronary angiogram or coronary angioplasty procedure will have measurements of blood pressure, coronary pressure and coronary flow made during pacing at a range of heart rates.
Able to give valid consent
Referred for coronary angiography or coronary angioplasty
Suitable for percutaneous physiological interrogation and PCI when clinically indicated
Unable to give valid consent
Pregnant or breastfeeding women
Unstable coronary artery disease (acute coronary syndrome)
Severe multivessel coronary artery disease suitable for coronary artery bypass grafting
Adults referred for coronary angiography or coronary angioplasty.
Cohort
Prospective
Pressure and flow measurement during simulated VT
Diagnostic testParticipants undergoing coronary angiography will have measurements of blood pressure, coronary pressure and coronary flow during simulated VT. VT will be simulated using pacing at a range of heart rates.
Change in coronary flow in participants with different levels of coronary microvascular function.
Change in coronary flow in participants immediately before and after PCI
Change in blood pressure in participants with different levels of coronary microvascular function.
Change in blood pressure in participants before and after PCI
Change in coronary flow in participants with different levels of left ventricular function
Change in blood pressure in participants with different levels of left ventricular function
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