Correlation Analysis of POD and pNCD in Elderly Patients With Gastrointestinal Neoplasms
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age65-100
SponsorXuanwu Hospital, Beijing
About this trial
This is a prospective cohort study to explore the differences of serum indicators between elderly gastrointestinal neoplasms patients with postoperative delirium (POD) who either develop or do not develop long-term postoperative neurocognitive disorders (pNCD).
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients ≥65 years of age who have undergone surgical anesthesia of gastrointestinal neoplasms; Sign informed consent.
Disqualifiers
Inability to complete cognitive function assessment; Illiteracy, hearing impairment or visual impairment; He has a history of epilepsy, depression, schizophrenia, Alzheimer's disease and other psychiatric and neurological diseases.
Trial population
Patients 65\~100 years of age who have undergone surgical anesthesia of gastrointestinal neoplasms
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
no intervention
Other interventionthis is an observation study, no intervention
Treatment groups
165 Participants
are divided into 1 treatment groupGroup A: postoperative delirium(POD) and postoperative neurocognitive disorder(pNCD)1 intervention
Trial outcomes
Primary outcomes
1
the changes of blood biomarkers before and after surgery between elderly gastrointestinal neoplasms patients with postoperative delirium (POD) who either develop or do not develop postoperative neurocognitive disorders (pNCD) one month after surgery
Perioperative changes in blood-based biomarkers can reflect the pathophysiological processes of diseases. Current studies indicate that the perioperative levels of blood-based biomarkers may be associated with postoperative neurocognitive disorders in elderly patients. These blood-based biomarkers may provide novel avenues for the early diagnosis, prevention, and improvement of outcomes in elderly patients with postoperative neurocognitive disorders. The procedures are as follows: Neurocognitive function assessments were conducted on the enrolled patients within one week before surgery, one month after surgery, and twelve months after surgery, respectively. Whether the patients developed postoperative delirium was evaluated within seven days after surgery. Venous blood was drawn before surgery and within three days after surgery to detect the levels of brain-derived neurotrophic factor (BDNF), high-sensitivity C-reactive protein (hs-CRP), and homocysteine (Hcy).
Time frame
2024.5.9-2026.6.1Sponsors and contacts
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Source ClinicalTrials.gov