Correlation Analysis of POD and pNCD in Elderly Spinal Surgery Patients
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age65-100
SponsorXuanwu Hospital, Beijing
About this trial
This study is a prospective cohort study to investigate the differences in serum indexes between elderly spinal surgery patients with postoperative delirium (POD) who either develop or do not develop long-term postoperative neurocognitive disorders (pNCD).
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients ≥65 years of age who have undergone spinal surgery anesthesia; Sign informed consent
Disqualifiers
Inability to complete cognitive function assessment; Illiteracy, hearing impairment or visual impairment; He has a history of epilepsy, depression, schizophrenia, Alzheimer's disease and other psychiatric and neurological diseases
Trial population
Patients 65\~100 years of age who have undergone spinal surgical anesthesia
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
no intervention
Other interventionthis is an observation study,no intervention
Treatment groups
165 Participants
are divided into 1 treatment groupGroup A: postoperative delirium(POD) and postoperative neurocognitive disorder(pNCD)1 intervention
Trial outcomes
Primary outcomes
1
change in serum indexes between elderly spinal patients with postoperative delirium(POD) who either develop or do not develop postoperative neurocognitive disorders (pNCD) one month after surgery
Perioperative neurocognitive disorders (PND) represent one of the common complications of general anesthesia, posing serious hazards and currently being a hot topic and a challenging problem in international research. Recently, general anesthesia has led to a new breakthrough in the study of PND serum-related markers, such as brain-derived nutritional factors(BDNF)、C-reactive protein(CRP)、homocysteine(Hcy). This provides new perspectives for PND prevention, evaluation and furnishes theoretical grounds for enhancing the safety of clinical anesthesia and the quality of life for patients.
Time frame
2024.5.9-2026.5.1Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov