Correlation of Cardiac Output Determined by Echocardiography and Indirect Calorimetry in Critically Ill Patients in Cardiogenic Shock on Extracorporeal Circulatory Life Support

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversität Münster

About this trial

This observational study investigates whether the daily measured trend of cardiac output as evaluated by indirect calorimetry correlates with the same evaluated by transthoracic echocardiography.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients that received cardiac surgery

Perioperative requirement of extracorporeal life support (ECLS)

Age ≥ 18 years

Informed consent

Disqualifiers

Pregnancy or breastfeeding

Relationship or dependency with the study sponsor

Expected survival less than 72 hours after screening

Trial population

Patients of a university hospital

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Correlation of t two methods of determining cardiac output (determined by transthoracic echocardiography and determined by indirect calorimetry

1. Transthoracic echocardiography.:For this purpose, the diameter of the left ventricular outflow tract (LVOT) is measured echocardiographically. Furthermore, the velocity-time integral (VTI) is determined echocardiographically as an approximation of the flow per heartbeat. If this VTI is multiplied by the cross section of the left ventricular outflow tract and the heart rate, the cardiac CO can be estimated. 2. Indirect calorimetry. This is calculated as follows: Cardiac CO = (Calorimetry-VO2/ECLS-VO2)\*ECLS Blood Flow. For this purpose, calorimetry VO2 is measured directly and ECLS VO2 is calculated using the avDO2 (ECLS O2 content of the arterial cannula minus venous cannula) multiplied by the ECLS blood flow. This shortens the ECLS blood flow. It remains: CO = calorimetry-VO2/avDO2-ECLS.

Time frame
On the day of admission to the intensive care unit and immediately before ECLS explantation

Secondary outcomes

Other outcomes

Sponsors and contacts

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