This study aims to examine the correlation between Fractional Flow Reserve (FFR) FFR Computed Tomography (CT) and invasive FFR in a real-world setting using retrospective analysis of existing data, providing practical insights directly applicable to patient care. By confirming or examining the accuracy of FFR CT in a clinical setting, our analysis could support its broader adoption as a routine non-invasive diagnostic tool potentially (a) reducing the need for invasive testing (b) minimising associated risks, and(c) lowering healthcare costs and provide fresh insights into non-invasive coronary diagnostics. Our findings will also help understand the relevance of these tests across different ethnic groups and the population we serve.
•≥18 years
Stable •patients with suspected CAD
Patients who underwent CTCA, FFR CT and had an invasive FFR.
CTCA images of high-quality for analysis, with clear visualisation of coronary arteries and minimal artifacts.
•<18 years of age
Did not undergo FFR CT
Inadequate quality/degraded CTCA images
The existing CTCA database for patients treated at Sandwell and West Birmingham NHS Trust between January 1, 2019, and December 31, 2023, with the clinical team screening the database to identify patients who fit with the eligibility criteria.
Cohort
Retrospective
Not listed
Correlation between FFR CT and invasive FFR.
Correlation as mesured by positive predicitve value, negative predictive value, sensitivity and specificity
Assess the downstream testing after FFR CT
By assessing the rates and results of invasive coronary angiography
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Sandwell & West Birmingham Hospitals NHS Trust
Lead sponsor
Aston University
Collaborator
