To evaluate whether the measurement of urinary estrone glucuronide and luteinizing hormone (LH) concentrations with an at-home device is correlated with serum hormone levels within a natural cycle frozen embryo transfer protocol.
The hypothesis is that home urinary monitoring can reliably detect the LH surge and serve as a trigger for timing the FET. Results of this study may ultimately lead to change in clinical practice by reducing the number of clinic visits for serum monitoring, offering a more convenient, time and cost saving method of detection of LH surge. If the proposed protocol were feasible and widely accepted by patients, this would prompt the wide adoption of a less invasive but equally as effective FET protocol.
All patients scheduled for a natural cycle frozen embryo transfer
Agree to participate in the research study
There are no exclusions
Participants that are presenting for a natural cycle frozen embryo transfer at The Ottawa and Olive Fertility Centre's
Cohort
Prospective
MIRA Device
DeviceAt home diagnostic testing
average delay in days
delay in days of surge detection between the Mira device compared to the serum detection, corrected for the time of the tests.
Patient satisfaction Survey
evaluate patient satisfaction with the use of the Mira device and willingness to utilize this device as an alternative to daily serum monitoring
Progesterone metabolites
Evaluate the proportion of cycles that have a rise in PdG (a urinary progesterone metabolite) prior to or at the time of their LH surge
BhCG urine vs Blood
evaluate the correlation of urinary BhCG measurements relative to serum BhCG evaluation 12-14 days post embryo transfer.
Click on the lead sponsor to view all of their trials.
Ottawa Fertility Centre
Lead sponsor
Quanovate Tech Inc.
Collaborator
This trial is not recruiting at the moment. You can still explore other options:
