Cortical Plasticity in Spastic Diplegia After Selective Dorsal Rhizotomy

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age3-18
SponsorThe University of Texas Health Science Center, Houston

About this trial

The purpose of this study is to characterize the cortical connectivity changes in the brain of spastic diplegic children after Selective Dorsal Rhizotomy.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Children diagnosis with Spastic Diplegia and having Selective Dorsal Rhizotomy surgery

Disqualifiers

No Selective Dorsal Rhizotomy surgery

Trial design

Design model

Single group

Treatments tested in this trial

  • 3Tesla MRI with DTI-MRI and rsfcMRI under general anesthesia

    Procedure/Surgery

    2 post-operative MRI's at 2 months and 12 months

Treatment groups

15 Participants
are divided into 1 treatment group
Group A: 3Tesla MRI with DTI-MRI and rsfcMRIOther 1 intervention

Trial outcomes

Primary outcomes

1

Change in Fractional Anisotropy as assessed by brain MRI with diffusion tractography imaging (DTI) sequences

This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract after Selective Dorsal Rhizotomy (SDR).

Time frame
Baseline and 12 months
2

Change in Mean Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences

This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract Selective Dorsal Rhizotomy (SDR).

Time frame
Baseline and 12 months
3

Change in Radial Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences

This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract after Selective Dorsal Rhizotomy (SDR)

Time frame
Baseline and 12 months
4

Change in Axial Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences

This measure will be used to assess changes in the lower extremity fibers corticopyramidal tract after Selective Dorsal Rhizotomy (SDR)

Time frame
Baseline and 12 months

Secondary outcomes

Other outcomes

Sponsors and contacts

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