The goal of this observational study is to learn about how bariatric surgery affects the metabolism of cortisol.
The main question it aims to answer is whether changes in cortisol contribute to the development of reactive hypoglycemia?
100 individuals who have previously undergone bariatric surgery, are planned to be included.
Roux-en-Y gastric bypass
Gastric sleeve
Pregnancy and breastfeeding
Nephrotic syndrome (kidney disease with protein loss in urine), liver cirrhosis, or severe malnutrition, as these conditions reduce cortisol-binding globulin (CBG) levels, affecting total cortisol concentration
Use of corticosteroid medications, such as prednisolone
Use of opiod-containing medication
postbariatric patients
Cohort
Cross-sectional
Not listed
Changes in serum cortisol during mixed meal test
cortisol at nadir glucose during the mixed meal test - cortisol at the start of the meal test
ACTH test: Test of adrenal function
0 min: Cortisol and corticotropin 30 min: Cortisol, corticotropin Δ Cortisol (30-minute cortisol - 0-minute cortisol) Bloodsamples
Cortisol hormone profile
Bloodsamples of CBG, Cortisol, Cortisone
urinary cortisol: Ratio of cortisol/cortisone
24-hour urinary cortisol: Ratio of cortisol/cortisone Urine sampling for 24 hour
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