Cost-utility Analysis of Ambulatory Dose Escalation of Bispecific Antibodies in Multiple Myeloma.

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity Hospital, Toulouse

About this trial

Multiple myeloma is the second most common haematological cancer. Recent innovations have made it possible for relapsed/refractory patients to benefit from the innovative immunotherapy of bispecific antibodies. These antibodies stimulate the immune system to attack tumour cells. The treatment involves an escalating dose of three subcutaneous injections every 2 to 4 days for a total of about 10 days, followed by a weekly treatment phase.

The University Hospital of Toulouse was the first centre in France to offer outpatient dose escalation for this innovative treatment. This form of treatment depends on clinical and logistical feasibility. Where appropriate, patients are treated in a conventional unit. An analysis carried out at Toulouse University Hospital suggests a response to treatment, with no increased risk of complications in the outpatient setting. Patients' quality of life may also be unaffected. In addition, given the increasing demand for care in a context of finite resources, the economic evaluation of healthcare initiatives is becoming essential if we are to maintain a high-quality healthcare system that is accessible to all.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Relapsed and/or refractory multiple myeloma

Treated with teclistamab, elranatamab ou talquetamab

More than 18 years old

Having received the information from the study and not having objected to participate

Disqualifiers

Illiterate subjects or those with a language barrier

Trial population

Study proposed during haematology consultation at the IUCT-Oncopole, detailing the care plan.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

40 Participants
are grouped into 2 trial groups
Group A: Outpatient step-up dose procedure
Group B: Conventional procedure

Trial outcomes

Primary outcomes

1

Efficiency

Cost of the procedure for health system and quality-adjusted life year calculated from the generic EQ-5D-5L questionnaire

Time frame
30 days

Secondary outcomes

Other outcomes

Sponsors and contacts

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