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CPET in Myocardial Ischemia

ConditionMyocardial Ischemia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorKuopio University Hospital

About this trial

The investigators goal is to determine whether cardiopulmonary exercise testing (CPET) can be utilized in the diagnosis of myocardial ischemia. For the study participants the investigators will recruit patients who have been referred to myocardial perfusion PET/CT scan in Kuopio University Hospital. The participants will perform the CPET on a cycle ergometer on separate day after the perfusion scan. The investigators will compare the results of the PET/CT scan and CPET and evaluate if the possible perfusion defects detected in PET/CT correlate with the gas exchange parameters in CPET.

The patients who receive invasive coronary treatment (coronary bypass surgery or percutaneous coronary intervention) will be invited to perform additional CPET ja PET/CT tests six months after the treatment. The goal will be to determine whether the recovery of myocardial perfusion can be assessed with gas exchange parameters in CPET.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Referral to coronary perfusion PET/CT scan in Kuopio University Hospital

Disqualifiers

Age under 18 years

Pregnancy or breastfeeding

Handicap

Imprisonment

Trial design

Design model

Single group

Treatments tested in this trial

  • Invasive coronary treatment

    Procedure/Surgery

    Coronary artery bypass surgery or percutaneous coronary intervention.

Treatment groups

100 Participants
are divided into 1 treatment group
Group A: Coronary perfusion PET/CT patientsOther 1 intervention

Trial outcomes

Primary outcomes

1

Presence of myocardial ischemia assessed by the myocardial perfusion positron emission tomography

Regional myocardial perfusion below 2.3 ml/g/min measured by the quantitative positron emission tomography is a marker of myocardial ischemia

Time frame
6 months
2

Presence of myocardial ischemia assessed by the cardiopulmanary exercise test

Criteria for myocardial ischemia that must be fulfilled are 1) Double sloping in the oxygen consumption/work rate trajectory, peak oxygen consumption below limit of the lowest normal, and abnormal oxygen pulse trajectory during the cardiopulmonary exercise test.

Time frame
6 months

Secondary outcomes

Other outcomes

1

Agreement in the detected myocardial ischemia between the myocardial perfusion positron emission tomography and the cardiopulmonary exercise testing

Positron emission tomography is the golden standard in the detection of myocardial ischemia. Results of cardiopulmary exercise testing will be compared with those of positron emission tomography using ROC-analysis. 6 months follow-up enables evaluation of reversibility of changes.

Time frame
6 months

Sponsors and contacts

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Kuopio University Hospital

Lead sponsor

Source ClinicalTrials.gov
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