Creatine and Perioperative Brain Health

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60-85
SponsorMassachusetts General Hospital

About this trial

The overall goal of this study is to evaluate the feasibility of perioperative oral creatine supplementation and to explore its effects on cognitive function and physiological responses to surgery in older adults. Creatine is commonly used to enhance athletic performance, but it can also have positive effects on the brain. Since surgery can alter thinking, memory, and attention patterns in some patients, we will assess whether creatine affects these changes in older adults undergoing surgery.

Eligibility criteria

Qualifiers

Patients scheduled for elective surgery under general anesthesia

Disqualifiers

History of creatine deficiency disorders

Renal or neurodegenerative disorders

History of stroke or significant head trauma, presence of intracranial mass lesions

Inability to give informed consent

Trial design

Treatments tested in this trial

  • Creatine monohydrate
  • Placebo

Treatment groups

120 Participants
are divided into 2 treatment groups

Locations

This trial has no locations

Sponsors and collaborators