Health TrialsbyHealthPanel

Creatine Supplementation During GLP-1a Therapy

ConditionSarcopenia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Saskatchewan

About this trial

GLP-1 receptor agonists are effective for weight loss, but significant muscle mass is lost as a proportion of this weight loss. This study combines resistance-training and creatine supplementation to try to prevent this loss of muscle mass.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Starting GLP-1 agonist therapy

18 years of age or older

Disqualifiers

Positive answers to a screening questionnaire for physical activity safety (the Get Active Questionnaire)

Trial design

Design model

Parallel

Treatments tested in this trial

  • Dietary supplementation during a 12 week resistance-training program (creatine)

    Dietary supplement

    creatine supplementation

  • Dietary supplementation during a 12 week resistance-training program (placebo)

    Dietary supplement

    Placebo

Treatment groups

40 Participants
are divided into 2 treatment groups
Group A: CreatineExperimental treatment 1 intervention
Group B: PlaceboPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Change in sit to stand performance (number of times)

change in number of times sitting and standing in 30 seconds

Time frame
12 weeks

Secondary outcomes

1

Change in 10 meter gait speed (m/s)

change in walking speed over 10 meters

Time frame
12 weeks
2

Change in timed up and go (m/s)

change in time to stand up, walk 3m, turn, around, walk 3 m and sit down

Time frame
12 weeks
3

Change in lean tissue mass (kg)

Change in lean tissue mass as determined by dual energy x-ray absorptiometry

Time frame
12 weeks
4

Change in fat mass (kg)

Change in fat mass as determined by dual energy x-ray absorptiometry

Time frame
12 weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Saskatchewan

Lead sponsor

Source ClinicalTrials.gov
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