Critical Illness After Hematopoietic Cell Transplantation

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorPeking University People's Hospital

About this trial

This is a prospective, multicenter observational trial for patients who develop critical illness after hematopoietic cell transplantation. Patients who are admitted to the intensive care unit after undergoing hematopoietic cell transplantation at the participating medical centers will be enrolled in this study. The clinical characteristics, laboratory profiles, managements, and clinical outcomes will be prospectively collected.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients who underwent hematopoietic cell transplantation at any of the participating medical centers.

Patients who are admitted to ICU for the management of critical illness following hematopoietic cell transplantation.

Disqualifiers

Admitted to ICU for a reason other than critical illness (e.g., routine postoperative monitoring) and discharged within 2 days of ICU admission.

Unavailable in-ICU clinical outcomes or absent key baseline characteristics.

Any other conditions that, in the opinion of the investigator, can interfere with the interpretation of data.

Trial population

Patients who are admitted to ICU after undergoing hematopoietic cell transplantation at any of the participating medical centers.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

4,000 Participants
are grouped into 1 trial group
Group A: Critically ill patients after hematopoietic cell transplantation

Trial outcomes

Primary outcomes

1

Overall survival

Overall survival after admission to the intensive care unit.

Time frame
Before ICU discharge; within 6 months after ICU discharge; and within 1 year after ICU discharge.

Secondary outcomes

1

Non-relapse mortality

Non-relapse mortality after ICU admission.

Time frame
Before ICU discharge; within 6 months after ICU discharge; and within 1 year after ICU discharge.
2

Relapse

Disease relapse or progression at or after ICU admission.

Time frame
At ICU admission and within 1 year of ICU discharge.
3

Transplant complication

Hematopoietic-cell-transplantation-associated complications at or after ICU admission.

Time frame
At ICU admission and within 1 year of ICU discharge.
4

Organ failure

Organ failure occurring at or after ICU admission.

Time frame
At ICU admission and within 1 year of ICU discharge.

Other outcomes

Sponsors and contacts

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Peking University People's Hospital

Lead sponsor

Hematology Hospital of Chinese Academy of Medical Sciences (Hematology Research Center of Chinese Academy of Medical Sciences)

Collaborator

Xinqiao hospital of the third military medical university

Collaborator

First Affiliated Hospital of Zhejiang University

Collaborator

First Affiliated Hospital of Harbin Medical University

Collaborator

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Collaborator

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