CUHK Stroke Biobank
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorChinese University of Hong Kong
About this trial
The purpose of the study are:
1. To make quality, characterized samples and related data available for future studies, including Genome Wide Association Studies (GWAS), genomics, and biomarker research; 2. To use these samples and related medical information to answer research questions aimed at understanding the genetics and underlying biology of acquired disease and injury to the brain, heart and blood vessels with the express purpose of advancing the search for effective modalities for prevention, treatment, and recovery; 3. To develop additional operational infrastructure to support this project across the Prince of Wales Hospital and divisions, including (1) tracking of patient consent, (2) management of collection and sample processing processes, (3) sample inventory and QC/QA processes, and (4) release of materials to investigators for further research.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adult equal or more 18 years of age and Chinese ONLY.
Stroke patients, their family members, and/or the normal subjects without intracranial stenosis or extracranial stenosis, are eligible to join the study.
Subject is willing to have blood taken, cerebral spinal fluid and/or body tissue drawn for storage in the research bank.
Disqualifiers
None
Trial population
1. Chinese ONLY 2. Patients with intracranial stenosis or extracranial stenosis equal to or \>70% 3. Stroke patients and their family members 4. Normal subject without any intracranial stenosis/ extracranial stenosis
Trial design
Design model
Other
Time perspective
Other
Treatments tested in this trial
Gene expression or biomarkers exploration
Genetic
Treatment groups
500 Participants
are divided into 3 treatment groupsGroup A: Atherosclerosis1 intervention
Group B: Family members1 intervention
Group C: Normal subjects1 intervention
Trial outcomes
Primary outcomes
1
Ischemic stroke-related genetics
1. Discovery of novel genetic predictor of stroke and its complications will be done by identifying cases and controls for different stroke subtype and complications within the recruited samples, and using whole-genome genotyping arrays, or by sequencing approaches. 2. Replication of novel genetic markers of stroke will be performed using a combination of genotyping, multiplex genotyping, customized-content genotyping arrays and sequencing.
Time frame
Dec, 2025Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov